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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2AK4 All Species: 26.06
Human Site: Y1196 Identified Species: 57.33
UniProt: Q9P2K8 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9P2K8 NP_001013725.2 1649 186838 Y1196 P A L Q E R N Y S I Y L N H T
Chimpanzee Pan troglodytes XP_001140245 1649 186793 Y1196 P A L Q E R N Y S I Y L N H T
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535431 1633 184740 Y1198 P A L Q E R N Y S I Y L N H T
Cat Felis silvestris
Mouse Mus musculus Q9QZ05 1648 186468 Y1195 P A L Q E R N Y S I Y L N H T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518247 1608 180821 Y1155 P G L Q E R N Y N V F L N H T
Chicken Gallus gallus XP_421203 1656 188583 Y1202 S V L Q E R N Y S I Y L N H T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002667149 1483 168725 Y1069 N I S H L K R Y S I E R V F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120977 1130 130476 D716 S I L R D A R D G K F T R F Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785160 1605 181469 S1188 V T N L K R Y S I E R V Y R E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LX30 1241 140303 C827 P M R L L S D C P Q F S R K T
Baker's Yeast Sacchar. cerevisiae P15442 1659 190175 T1175 P V F E K T N T F F I L N H A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 N.A. 89.7 N.A. 90.5 N.A. N.A. 74.7 72.3 N.A. 52.6 N.A. N.A. 27.9 N.A. 40.4
Protein Similarity: 100 99.9 N.A. 94.3 N.A. 94.9 N.A. N.A. 84.4 84.5 N.A. 67.4 N.A. N.A. 44 N.A. 59.4
P-Site Identity: 100 100 N.A. 100 N.A. 100 N.A. N.A. 73.3 86.6 N.A. 20 N.A. N.A. 6.6 N.A. 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. 93.3 86.6 N.A. 26.6 N.A. N.A. 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 22.5 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. 39.7 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 37 0 0 0 10 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 10 10 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 55 0 0 0 0 10 10 0 0 0 10 % E
% Phe: 0 0 10 0 0 0 0 0 10 10 28 0 0 19 0 % F
% Gly: 0 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 64 0 % H
% Ile: 0 19 0 0 0 0 0 0 10 55 10 0 0 0 0 % I
% Lys: 0 0 0 0 19 10 0 0 0 10 0 0 0 10 0 % K
% Leu: 0 0 64 19 19 0 0 0 0 0 0 64 0 0 0 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 0 0 64 0 10 0 0 0 64 0 0 % N
% Pro: 64 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % P
% Gln: 0 0 0 55 0 0 0 0 0 10 0 0 0 0 10 % Q
% Arg: 0 0 10 10 0 64 19 0 0 0 10 10 19 10 10 % R
% Ser: 19 0 10 0 0 10 0 10 55 0 0 10 0 0 0 % S
% Thr: 0 10 0 0 0 10 0 10 0 0 0 10 0 0 64 % T
% Val: 10 19 0 0 0 0 0 0 0 10 0 10 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 64 0 0 46 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _